fabL [2018-02-12T03:52:03.000Z]

enoyl-acyl carrier protein reductase

Locus: BSU08650

Isoelectric point: 5.97

Molecular weight: 27.03 kDa

Protein length: 250 aa

Gene length: 750 bp

Function: fatty acid biosynthesis

Product: enoyl-acyl carrier protein reductase

Essential: no

Synonyms: yfhR,ygaA

Genomic Context

Loading

Categories containing this gene/protein

• Metabolism → Lipid metabolism → Biosynthesis of lipids → Biosynthesis of fatty acids
• Lifestyles → Sporulation → Sporulation proteins → Sporulation proteins/ other

Gene

Coordinates: 937,079 → 937,831

The protein

Paralogous protein(s)

• FabI, one of the two proteins has to be present for viability PubMed, YcdF, YhdF, YkvO

Structure

• 3OIC PubMed

Expression and Regulation

Operons

• Genes: fabL-sspE
  Description: PubMed

  Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon
  • SigG: sigma factor, PubMed, in SigG regulon

  Regulatory mechanism

  • SpoVT: repression, in SpoVT regulon
  • YfhP: repression, in YfhP regulon

  Regulation

  • repressed by casamino acids PubMed

• Genes: mutY-fabL-sspE
  Description: PubMed

  Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon
  • SigG: sigma factor, PubMed, in SigG regulon

  Regulatory mechanism

  • YfhP: repression, in YfhP regulon

  Regulation

  • expression is constitutive throughout growth PubMed

Biological materials

Mutant

• MGNA-C324 (yfhR::erm), available at the NBRP B. subtilis, Japan
• BKE08650 (ΔfabL::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATTTTTCCTCATCTCCTTG, downstream forward: _UP4_TAAAAATTTTTAAAAAAGAG
• BKK08650 (ΔfabL::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATTTTTCCTCATCTCCTTG, downstream forward: _UP4_TAAAAATTTTTAAAAAAGAG

References

Reviews

Loading

Original Publications

Loading